Diseases are typically inhaled contagions (though these are usually filtered out by a Standard Space Suit or suit of armor) or injury contagions. If a disease lacks a Cure entry, its progression may be irreversible without powerful magic or technology, but a successful casting of remove affliction usually prevents further deterioration. Physical and mental Diseases have separate tracks.

Physical Disease Track

Healthy—Latent—Weakened—Impaired—Debilitated— Bedridden—Comatose—Dead

Latent

The victim has contracted a disease. She suffers no ill effects yet, but if the disease is contagious, she can pass it on.

Weakened

The victim is Sickened and Fatigued.

Impaired

The victim is Exhausted. Whenever she takes a Standard or Full Action, she must succeed at a Fortitude save at the disease's DC or lose the action and become Nauseated for 1 minute.

Debilitated

Strenuous actions cause the victim pain. If she takes a Standard action, she immediately loses 1 Hit Point.

Bedridden

The victim is awake and can converse, but she can't stand on her own or take any Other Actions or Reactions.

Comatose

The victim is unconscious and feverish, and can't be woken.

Dead

The victim is dead, and her corpse may still be contagious.

Mental Disease Track

Healthy—Latent—Weakened—Impaired—Befuddled— Disassociated—Comatose—Dead

Latent

The victim can pass on contagious Diseases but suffers no ill effects.

Weakened

The victim is Shaken, and the DCs of his spells and Special Abilities decrease by 2. He can no longer cast his highest level of spells (if any).

Impaired

The victim is Flat-Footed and no longer adds his mental Ability Score Modifiers when calculating number of uses per day of abilities dependent on those scores, including bonus spells per day. The DCs of his spells and Special Abilities decrease by an additional 2. He can no longer cast his 2 highest levels of spells (if any).

Befuddled

The victim begins losing his grasp on thought, reality, and self. He has a 50% chance each round to take no relevant actions, instead babbling randomly, wandering off, or talking to unseen parties.

Disassociated

The victim is almost entirely disconnected from reality. His mind filters and twists all external stimuli into strange forms. He can no longer tell friend from foe and can't willingly accept any aid (including healing) from another Creature unless he succeeds at a Will save against the disease's DC.

Comatose

A victim rendered comatose by a mental disease has lost all grip on reality and entered a dream world. He can't be woken.

Dead

The victim is dead, and his corpse may still be contagious.