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Generally, when you are subject to an unusual or magical attack, you get a Saving Throw to avoid or reduce the effect. Like an attack roll, a Saving Throw is a d20 roll plus a bonus based on your class and level (see Classes), and an associated Ability Score. Your Saving Throw modifier is:
Base save bonus + ability modifier
Saving Throw Types: The three different kinds of saving throws are Fortitude, Reflex, and Will:
Fortitude: These saves measure your ability to stand up to physical punishment or attacks against your vitality and health. Apply your Constitution modifier to your Fortitude saving throws.
Reflex: These saves test your ability to dodge area attacks and unexpected situations. Apply your Dexterity modifier to your Reflex saving throws.
Automatic Failures and Successes: A natural 1 (the d20 comes up 1) on a Saving Throw is always a failure (and may cause Damage to exposed items; see Items Surviving after a Saving Throw). A natural 20 (the d20 comes up 20) is always a success.